Repositioning Candidate Details
| Candidate ID: | R0422 |
| Source ID: | DB01140 |
| Source Type: | approved; vet_approved; withdrawn |
| Compound Type: | small molecule |
| Compound Name: | Cefadroxil |
| Synonyms: | CDX; Cefadroxil; Cefadroxil anhydrous; Cephadroxil; D-Cefadroxil |
| Molecular Formula: | C16H17N3O5S |
| SMILES: | [H][C@]12SCC(C)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)C1=CC=C(O)C=C1)C(O)=O |
| Structure: |
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| DrugBank Description: | Long-acting, broad-spectrum, water-soluble, cephalexin derivative. |
| CAS Number: | 50370-12-2 |
| Molecular Weight: | 363.388 |
| DrugBank Indication: | For the treatment of the following infections (skin, UTI, ENT) caused by; <i>S. pneumoniae, H. influenzae, staphylococci, S. pyogenes</i> (group A beta-hemolytic streptococci), <i>E. coli, P. mirabilis, Klebsiella</i> sp, coagulase-negative staphylococci and <i>Streptococcus pyogenes</i> |
| DrugBank Pharmacology: | Cefadroxil, a first-generation cephalosporin antibiotic, is used to treat urinary tract infections, skin and skin structure infections, pharyngitis, and tonsillitis. |
| DrugBank MoA: | Like all beta-lactam antibiotics, cefadroxil binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefadroxil interferes with an autolysin inhibitor. |
| Targets: | Penicillin-binding protein 3 inhibitor; Penicillin-binding protein 1A inhibitor; Penicillin-binding protein 1b inhibitor; Penicillin-binding protein 2B inhibitor |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I01 | 552 | Pneumonia | A lung disease that involves lung parenchyma or alveolar inflammation and abnormal alveolar filling with fluid (consolidation and exudation). It results from a variety of causes including infection with bacteria, viruses, fungi or parasites, and chemical or physical injury to the lungs. It is accompanied by fever, chills, cough, and difficulty in breathing. http://en.wikipedia.org/wiki/Pneumonia | disease of anatomical entity/respiratory system disease/ lower respiratory tract disease/lung disease | Details |
| I09 | 104 | Bacterial infectious disease | A disease by infectious agent that results_in infection, has_material_basis_in Bacteria. http://en.wikipedia.org/wiki/Pathogenic_bacteria | disease by infectious agent | Details |