Repositioning Candidate Details
| Candidate ID: | R0449 |
| Source ID: | DB01210 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Levobunolol |
| Synonyms: | (-)-Bunolol; (S)-5-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-3,4-dihydro-1(2H)-naphthalenone; Levobunolol |
| Molecular Formula: | C17H25NO3 |
| SMILES: | CC(C)(C)NC[C@H](O)COC1=CC=CC2=C1CCCC2=O |
| Structure: |
|
| DrugBank Description: | A nonselective beta-adrenoceptor antagonist used in the treatment of glaucoma. |
| CAS Number: | 47141-42-4 |
| Molecular Weight: | 291.3853 |
| DrugBank Indication: | For lowering intraocular pressure (IOP) and may be used in patients with chronic open-angle glaucoma or ocular hypertension. |
| DrugBank Pharmacology: | Levobunolol is an ophthalmic beta-blocker, equally effective at β(1)- and β(2)-receptor sites. Levobunolol reduces both elevated and normal IOP in patients with or without glaucoma. In patients with elevated IOP, levobunolol reduces mean IOP by approximately 25-40% from baseline. As the drug is a nonselective &beta-adrenergic blocking agent, it can produce both systemic pulmonary and cardiovascular effects following topical application to the eye. These effects include adverse pulmonary effects (eg. bronchoconstriction, increased airway resistance), and a decrease in blood pressure and heart rate. |
| DrugBank MoA: | Levobunolol's mechanism of action in reducing IOP is not clearly defined, but is believed to be due to a reduction of the production of aqueous humor via blockage of endogenous catecholamine-stimulated increases in cyclic adenosine monophosphate (AMP) concentrations within the ciliary processes. |
| Targets: | Beta-2 adrenergic receptor antagonist; Beta-1 adrenergic receptor antagonist |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I12 | 10763 | Hypertension | An artery disease characterized by chronic elevated blood pressure in the arteries. https://en.wikipedia.org/wiki/Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/24352797 | disease of anatomical entity/ cardiovascular system disease/vascular disease/ artery disease | Details |