Repositioning Candidate Details
| Candidate ID: | R0468 |
| Source ID: | DB01252 |
| Source Type: | investigational |
| Compound Type: | small molecule |
| Compound Name: | Mitiglinide |
| Synonyms: | Mitiglinide |
| Molecular Formula: | C19H25NO3 |
| SMILES: | [H][C@@](CC(=O)N1C[C@@]2([H])CCCC[C@@]2([H])C1)(CC1=CC=CC=C1)C(O)=O |
| Structure: |
|
| DrugBank Description: | Mitiglinide is a drug for the treatment of type 2 diabetes. It may stimulate insulin secretion in beta-cells by closing off ATP dependant potassium ion channels. |
| CAS Number: | 145375-43-5 |
| Molecular Weight: | 315.413 |
| DrugBank Indication: | For the treatment of type 2 diabetes. |
| DrugBank Pharmacology: | Mitiglinide belongs to the meglitinide class of blood glucose-lowering drugs. It is approved for use in Japan but has not yet gained FDA approval. |
| DrugBank MoA: | Mitiglinide is thought to stimulate insulin secretion by binding to and blocking ATP-sensitive K(+) (K(ATP)) channels (Kir6.2/SUR1 complex, KATP channels) in pancreatic beta-cells. Closure of potassium channels causes depolarization which stimulates calcium influx through voltage-gated calcium channels. High intracellular calcium subsequently triggers the exocytosis of insulin granules. |
| Targets: | ATP-binding cassette sub-family C member 8 inhibitor; Peroxisome proliferator-activated receptor gamma agonist |
| Inclusion Criteria: | Target associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I05 | 9352 | Type 2 diabetes mellitus | A diabetes that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. http://en.wikipedia.org/wiki/Diabetes, http://en.wikipedia.org/wiki/Diabetes_mellitus_type_2 | disease of metabolism/inherited metabolic disorder/ carbohydrate metabolic disorder/glucose metabolism disease/diabetes/ diabetes mellitus | Details |