Repositioning Candidate Details
| Candidate ID: | R0470 |
| Source ID: | DB01260 |
| Source Type: | approved; investigational |
| Compound Type: | small molecule |
| Compound Name: | Desonide |
| Synonyms: | 11β,21-dihydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione; 11β,21-dihydroxy-16α,17-isopropylidenedioxypregna-1,4-diene-3,20-dione; 11β,21-dihydroxy-16α,17α-isopropylidenedioxypregna-1,4-diene-3,20-dione; 16α-hydroxyprednisole-16,17-acetonide; 16α-hydroxyprednisolone-16α,17-acetonide; 16α,17α-isopropylidenedioxyprednisolone; Desfluorotriamcinolone acetonide; Desonide |
| Molecular Formula: | C24H32O6 |
| SMILES: | [H][C@@]12C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)C=C[C@]12C |
| Structure: |
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| DrugBank Description: | A nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses. |
| CAS Number: | 638-94-8 |
| Molecular Weight: | 416.5073 |
| DrugBank Indication: | For the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatose. |
| DrugBank Pharmacology: | Desonide is a synthetic nonfluorinated corticosteroid for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and antipruritic agents. |
| DrugBank MoA: | Like other topical corticosteroids, desonide has anti-inflammatory, antipruritic and vasoconstrictive properties. The drug binds to cytosolic glucocorticoid receptors. This complex migrates to the nucleus and binds to genetic elements on the DNA. This activates and represses various genes. However corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. |
| Targets: | Glucocorticoid receptor agonist |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class |
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