Repositioning Candidate Details
| Candidate ID: | R0490 |
| Source ID: | DB01324 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Polythiazide |
| Synonyms: | Polythiazide |
| Molecular Formula: | C11H13ClF3N3O4S3 |
| SMILES: | CN1C(CSCC(F)(F)F)NC2=CC(Cl)=C(C=C2S1(=O)=O)S(N)(=O)=O |
| Structure: |
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| DrugBank Description: | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) |
| CAS Number: | 346-18-9 |
| Molecular Weight: | 439.882 |
| DrugBank Indication: | Polythiazide is a thiazide diuretic used to decrease edema and decrease blood pressure. |
| DrugBank Pharmacology: | As a thiazide diuretic, Polythiazide inhibits the sodium-chloride symporter which decreases solute reabsorption leading to a retention of water in the urine, as water normally follows solutes. More frequent urination is due to the increased loss of water that has not been retained from the body as a result of a concomitant relationship with sodium loss from the convoluted tubule. The short-term anti-hypertensive action is based on the fact that thiazides decrease preload, decreasing blood pressure |
| DrugBank MoA: | As a diuretic, polythiazide inhibits active chloride reabsorption at the early distal tubule via the thiazide-sensitive Na-Cl cotransporter (TSC), resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like polythiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of polythiazide may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle. |
| Targets: | Solute carrier family 12 member 3 inhibitor |
| Inclusion Criteria: | Therapeutic strategy associated |
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