Repositioning Candidate Details
| Candidate ID: | R0504 |
| Source ID: | DB01377 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Magnesium oxide |
| Synonyms: | Magnesia; Magnesium oxide |
| Molecular Formula: | MgO |
| SMILES: | [O--].[Mg++] |
| Structure: |
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| DrugBank Description: | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. |
| CAS Number: | 1309-48-4 |
| Molecular Weight: | 40.304 |
| DrugBank Indication: | Indicated for over-the-counter use as a supplement for cardiovascular and neuromuscular health, and as an antacid for relief of acid indigestion and upset stomach. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | The term "Milk of Magnesia" was first used to describe a white aqueous, mildly alkaline suspension of magnesium hydroxide formulated at about 8%w/v. Milk of magnesia is primarily used to alleviate constipation, but can also be used to relieve indigestion and heartburn. When taken internally by mouth as a laxative, the osmotic force of the magnesia suspension acts to draw fluids from the body and to retain those already within the lumen of the intestine, serving to distend the bowel, thus stimulating nerves within the colon wall, inducing peristalsis and resulting in evacuation of colonic contents. Magnesium supplements have also been shown to reduce platelet aggregation by inhibiting in the influx of calcium, a crucial component of platelet aggregation. |
| Targets: | -- |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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