Repositioning Candidate Details
| Candidate ID: | R0518 |
| Source ID: | DB01414 |
| Source Type: | experimental; vet_approved |
| Compound Type: | small molecule |
| Compound Name: | Cefacetrile |
| Synonyms: | Cefacetrile; Cephacetrile |
| Molecular Formula: | C13H13N3O6S |
| SMILES: | [H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2NC(=O)CC#N)C(O)=O |
| Structure: |
|
| DrugBank Description: | A derivative of 7-aminocephalosporanic acid. |
| CAS Number: | 10206-21-0 |
| Molecular Weight: | 339.324 |
| DrugBank Indication: | Cefacetrile is a broad-spectrum first generation cephalosporin antibiotic effective in Gram-positive and Gram-negative bacterial infections. |
| DrugBank Pharmacology: | Cefacetrile is effective against many Gram-positive bacterial strains and somewhat less effective against Gram-negative species. It works by inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine. |
| DrugBank MoA: | In vitro tests demonstrate that the bactericidal action of cephalosporins results from inhibition of cell wall synthesis. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins. |
| Targets: | Penicillin-binding protein 1A inhibitor; Penicillin-binding protein 1B inhibitor |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class |
|---|