Repositioning Candidate Details
| Candidate ID: | R0521 |
| Source ID: | DB01424 |
| Source Type: | approved; withdrawn |
| Compound Type: | small molecule |
| Compound Name: | Aminophenazone |
| Synonyms: | (Dimethylamino)phenazone; 1-Phenyl-2,3-dimethyl-4-(dimethylamino)-5-pyrazolone; 1-Phenyl-2,3-dimethyl-4-dimethylaminopyrazol-5-one; 1,5-Dimethyl-4-dimethylamino-2-phenyl-3-pyrazolone; 2,3-Dimethyl-4-dimethylamino-1-phenyl-5-pyrazolone; 3-Keto-1,5-dimethyl-4-dimethylamino-2-phenyl-2,3-dihydropyrazole; 4-(Dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one; 4-(Dimethylamino)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one; 4-(Dimethylamino)antipyrine; 4-Dimethylamino-1-phenyl-2,3-dimethylpyrazolone; 4-Dimethylamino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one; 4-Dimethylamino-2,3-dimethyl-1-phenyl-5-pyrazolone; 4-Dimethylaminoantipyrine; 4-Dimethylaminophenazone; Aminofenazone; Aminophenazone; Aminopyrine; Dimethylaminoantipyrine; Dimethylaminoazophene; Dimethylaminophenazone; Dimethylaminophenyldimethylpyrazolone; Dipyrine |
| Molecular Formula: | C13H17N3O |
| SMILES: | CN(C)C1=C(C)N(C)N(C1=O)C1=CC=CC=C1 |
| Structure: |
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| DrugBank Description: | Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic properties that carries a risk of agranulocytosis. In biomedical applications, radiolabelled (13C-labeled) aminophenazone has been used in breath tests to measure the cytochrome P-450 metabolic activity in liver function tests. |
| CAS Number: | 58-15-1 |
| Molecular Weight: | 231.2936 |
| DrugBank Indication: | Formerly widely used as an antipyretic and analgesic in rheumatism, neuritis, and common colds. Currently used to measure total body water. |
| DrugBank Pharmacology: | Aminophenazone exhibits analgesic, anti-inflammatory, and antipyretic properties. |
| DrugBank MoA: | Aminophenazone is metabolized very slowly by normal newborn babies. In older infants, a higher amount of exhaled 13-CO2 is observed. |
| Targets: | -- |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class |
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