Repositioning Candidate Details
| Candidate ID: | R0528 |
| Source ID: | DB01556 |
| Source Type: | illicit; withdrawn |
| Compound Type: | small molecule |
| Compound Name: | Chlorphentermine |
| Synonyms: | 4-Chloro-a,a-dimethylbenzeneethanamine; 4-Chloro-a,a-dimethylphenethylamine; a,a-Dimethyl-p-chlorophenethylamine; Chlorphentermine |
| Molecular Formula: | C10H14ClN |
| SMILES: | CC(C)(N)CC1=CC=C(Cl)C=C1 |
| Structure: |
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| DrugBank Description: | A sympathomimetic agent that was formerly used as an anorectic. It has properties similar to those of dextroamphetamine. It has been implicated in lipid storage disorders and pulmonary hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1223) |
| CAS Number: | 461-78-9 |
| Molecular Weight: | 183.678 |
| DrugBank Indication: | Used as an appetite suppressant. |
| DrugBank Pharmacology: | Chlorphentermine is a relatively weak stimulant with little abuse potential. It presents a prominent serotonergic profile leading to pulmonary hypertension and cardiac fibrosis after prolonged use. Thus, this drug is no longer used. |
| DrugBank MoA: | -- |
| Targets: | -- |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S03 | Anti-fibrosis | fibrosis | Angiotensin Receptor Blocker (ARB); CCR2/CCR5 antagonist; Thyroid receptor β agonist; PEGylated human FGF21 analogue; Monoclonal antibody to lysyl oxidase-like 2 (LOXL2); Galectin-3 inhibitor; FGF19 variant | Losartan; Cenicriviroc; VK-2809; MGL-3196; Pegbelfermin; Simtuzumab; GR-MD-02; NGM282 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I12 | 10763 | Hypertension | An artery disease characterized by chronic elevated blood pressure in the arteries. https://en.wikipedia.org/wiki/Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/24352797 | disease of anatomical entity/ cardiovascular system disease/vascular disease/ artery disease | Details |