Repositioning Candidate Details
| Candidate ID: | R0530 |
| Source ID: | DB01577 |
| Source Type: | approved; illicit |
| Compound Type: | small molecule |
| Compound Name: | Metamfetamine |
| Synonyms: | (+)-(S)-N-α-dimethylphenethylamine; (S)-N,α-dimethylbenzeneethanamine; (αS)-N,α-dimethylbenzeneethanamine; d-1-phenyl-2-methylaminopropane; d-deoxyephedrine; d-desoxyephedrine; d-N-methylamphetamine; d-phenylisopropylmethylamine; Dextromethamphetamine; Metamfetamine; Methamphetamine; methyl-β-phenylisopropylamine |
| Molecular Formula: | C10H15N |
| SMILES: | CN[C@@H](C)CC1=CC=CC=C1 |
| Structure: |
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| DrugBank Description: | Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug. It is a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potential for addiction and abuse. |
| CAS Number: | 537-46-2 |
| Molecular Weight: | 149.2328 |
| DrugBank Indication: | For the treatment of Attention Deficit Disorder with Hyperactivity (ADHD) and exogenous obesity. |
| DrugBank Pharmacology: | Methamphetamine is a potent central nervous system stimulant which affects neurochemical mechanisms responsible for regulating heart rate, body temperature, blood pressure, appetite, attention, mood and responses associated with alertness or alarm conditions. The acute effects of the drug closely resemble the physiological and psychological effects of an epinephrine-provoked fight-or-flight response, including increased heart rate and blood pressure, vasoconstriction (constriction of the arterial walls), bronchodilation, and hyperglycemia (increased blood sugar). Users experience an increase in focus, increased mental alertness, and the elimination of fatigue, as well as a decrease in appetite. |
| DrugBank MoA: | Methamphetamine enters the brain and triggers a cascading release of norepinephrine, dopamine and serotonin. To a lesser extent methamphetamine acts as a dopaminergic and adrenergic reuptake inhibitor and in high concentrations as a monamine oxidase inhibitor (MAOI). The mechanism of action involved in producing the beneficial behavioral changes seen in hyperkinetic children receiving methamphetamine is unknown. |
| Targets: | Sodium-dependent dopamine transporter negative modulator; Sodium-dependent serotonin transporter negative modulator; Sodium-dependent noradrenaline transporter negative modulator; Synaptic vesicular amine transporter inhibitor; Chromaffin granule amine transporter inhibitor; Trace amine-associated receptor 1 agonist; Alpha-2A adrenergic receptor agonist; Alpha-2B adrenergic receptor agonist; Alpha-2C adrenergic receptor agonist; Amine oxidase [flavin-containing] A inhibitor; Amine oxidase [flavin-containing] B inhibitor |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I05 | 9352 | Type 2 diabetes mellitus | A diabetes that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. http://en.wikipedia.org/wiki/Diabetes, http://en.wikipedia.org/wiki/Diabetes_mellitus_type_2 | disease of metabolism/inherited metabolic disorder/ carbohydrate metabolic disorder/glucose metabolism disease/diabetes/ diabetes mellitus | Details |
| I14 | 9970 | Obesity | An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. https://en.wikipedia.org/wiki/Obesity | disease of metabolism/acquired metabolic disease/ nutrition disease/overnutrition | Details |