Repositioning Candidate Details
| Candidate ID: | R0539 |
| Source ID: | DB01600 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Tiaprofenic acid |
| Synonyms: | 2-(5-Benzoyl-thiophen-2-yl)-propionic acid; 5-benzoyl-α-methyl-2-thiopheneacetic acid; 5-benzoyl-α-methylthiophene-2-acetic acid; Tiaprofenic acid; α-methyl-5-benzoyl-2-thienylacetic acid |
| Molecular Formula: | C14H12O3S |
| SMILES: | CC(C(O)=O)C1=CC=C(S1)C(=O)C1=CC=CC=C1 |
| Structure: |
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| DrugBank Description: | Tiaprofenic acid is a non-steroidal anti-inflammatory drug employed in the treatment of pain, particularly arthritis pain. It belongs to the _arylpropionic acid_ (profen) group of nonsteroidal anti-inflammatory drugs (NSAIDs). |
| CAS Number: | 33005-95-7 |
| Molecular Weight: | 260.308 |
| DrugBank Indication: | Tiaprofenic acid is used to treat pain, especially arthritic pain. |
| DrugBank Pharmacology: | Tiaprofenic acid is a non-steroidal anti-inflammatory drug of the arylpropionic acid (profen) class, used to treat pain, especially arthritic pain. The typical adult dose is 300mg twice daily. This drug is not recommended for use in the pediatric population. |
| DrugBank MoA: | Tiaprofenic acid belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). It works by blocking the production of a chemical (prostaglandin) which the body produces in response to injury or certain diseases. This prostaglandin would otherwise go on to cause swelling, pain and inflammation. |
| Targets: | Prostaglandin G/H synthase 2 inhibitor; Prostaglandin G/H synthase 1 inhibitor |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I15 | 1290 | Bone disease | A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function. http://en.wikipedia.org/wiki/Bone_disease | disease of anatomical entity/ musculoskeletal system disease/connective tissue disease | Details |