Repositioning Candidate Details
| Candidate ID: | R0543 |
| Source ID: | DB01607 |
| Source Type: | approved; investigational; vet_approved |
| Compound Type: | small molecule |
| Compound Name: | Ticarcillin |
| Synonyms: | (2S,5R,6R)-6-{[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; Ticarcillin; α-carboxy-3-thienylmethylpenicillin |
| Molecular Formula: | C15H16N2O6S2 |
| SMILES: | [H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](C(O)=O)C1=CSC=C1)C(O)=O |
| Structure: |
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| DrugBank Description: | An antibiotic derived from penicillin similar to carbenicillin in action. |
| CAS Number: | 34787-01-4 |
| Molecular Weight: | 384.427 |
| DrugBank Indication: | For the treatment of bacterial infections. |
| DrugBank Pharmacology: | Ticarcillin is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria. Ticarcillin is, however, susceptible to degradation by ß-lactamases, and therefore, the spectrum of activity does not normally include organisms which produce these enzymes. |
| DrugBank MoA: | Ticarcillin's principal mechanism of action revolves around its capacity to prevent the cross-linking of peptidoglycan during bacterial cell wall synthesis. Consequently, when the offending bacteria attempt to undergo cell division, cell death occurs. |
| Targets: | Penicillin binding protein 2a inhibitor |
| Inclusion Criteria: | Indication associated |
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