Repositioning Candidate Details
| Candidate ID: | R0548 |
| Source ID: | DB01626 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Pargyline |
| Synonyms: | Pargyline |
| Molecular Formula: | C11H13N |
| SMILES: | CN(CC#C)CC1=CC=CC=C1 |
| Structure: |
|
| DrugBank Description: | Pargyline is a monoamine oxidase inhibitor with antihypertensive properties. |
| CAS Number: | 555-57-7 |
| Molecular Weight: | 159.2276 |
| DrugBank Indication: | For the treatment of moderate to severe hypertension. |
| DrugBank Pharmacology: | Pargyline is a monoamine oxidase B (MAO-B) inhibitor with antihypertensive properties. Patients taking pargyline must avoid concurrent consumption of tyramine-containing foods such as bleu cheese and beer, as this can lead to a hypertensive crisis. |
| DrugBank MoA: | MAOIs act by inhibiting the activity of monoamine oxidase, thus preventing the breakdown of monoamine neurotransmitters and thereby increasing their availability. There are two isoforms of monoamine oxidase, MAO-A and MAO-B. MAO-A preferentially deaminates serotonin, melatonin, epinephrine and norepinephrine. MAO-B preferentially deaminates phenylethylamine and trace amines. Pargyline functions by inhibiting the metabolism of catecholamines and tyramine within presynaptic nerve terminals. Catecholamines cause general physiological changes that prepare the body for physical activity (fight-or-flight response). Some typical effects are increases in heart rate, blood pressure, blood glucose levels, and a general reaction of the sympathetic nervous system. |
| Targets: | Amine oxidase [flavin-containing] B inhibitor; Amine oxidase [flavin-containing] A inhibitor |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I12 | 10763 | Hypertension | An artery disease characterized by chronic elevated blood pressure in the arteries. https://en.wikipedia.org/wiki/Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/24352797 | disease of anatomical entity/ cardiovascular system disease/vascular disease/ artery disease | Details |