Repositioning Candidate Details
| Candidate ID: | R0551 |
| Source ID: | DB01669 |
| Source Type: | experimental |
| Compound Type: | small molecule |
| Compound Name: | Virginiamycin M1 |
| Synonyms: | Mikamycin A; Ostreogrycin A; Pristinamycin IIA; Streptogramin A; Virginiamycin factor M1; Virginiamycin M1 |
| Molecular Formula: | C28H35N3O7 |
| SMILES: | CC(C)[C@H]1OC(=O)C2=CCCN2C(=O)C2=COC(=N2)CC(=O)C[C@H](O)\C=C(/C)\C=C\CNC(=O)\C=C\[C@H]1C |
| Structure: |
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| DrugBank Description: | Pristinamycin IIA is a macrolide antibiotic, a member of the streptogramin A group of antibiotics, and one component of pristinamycin. It is produced by Streptomyces graminofaciens and other bacteria. |
| CAS Number: | 21411-53-0 |
| Molecular Weight: | 525.5934 |
| DrugBank Indication: | For the treatment of bacterial infections. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | Virginiamycin M1 is a macrocyclic lactone antibiotic that acts syngeristically with the structurally unrelated cyclic depsipeptides more commonly known as the virginiamycins B (ostreogrycin B or streptogramin B) and S to inhibit peptide elongation. This is achieved by blocking formation of a peptide bond between the growing peptide chain (peptidyl-tRNA) linked to the 50S ribosome and aminoacyl-tRNA. Virginiamycin M1 has proven to be highly active against Gram positive bacteria, particularly methicillin-resistant S. aureus. |
| Targets: | Streptogramin A acetyltransferase |
| Inclusion Criteria: | Indication associated |
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