Repositioning Candidate Details
| Candidate ID: | R0560 |
| Source ID: | DB02266 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Flufenamic acid |
| Synonyms: | Flufenamic acid |
| Molecular Formula: | C14H10F3NO2 |
| SMILES: | OC(=O)C1=CC=CC=C1NC1=CC(=CC=C1)C(F)(F)F |
| Structure: |
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| DrugBank Description: | An anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically. (From Martindale, The Extra Pharmacopoeia, 30th ed, p16) |
| CAS Number: | 530-78-9 |
| Molecular Weight: | 281.2299 |
| DrugBank Indication: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | -- |
| Targets: | Prostaglandin G/H synthase 2; Prostaglandin G/H synthase 1; Aldo-keto reductase family 1 member C3; Androgen receptor; Peroxisome proliferator-activated receptor alpha activator; Peroxisome proliferator-activated receptor gamma agonist |
| Inclusion Criteria: | Target associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T03 | Peroxisome proliferator-activated receptor alpha | PPARA | agonist | Nuclear hormone receptor | Q07869 | PPARA_HUMAN | Details |
| T05 | Peroxisome proliferator-activated receptor gamma | PPARG | agonist | Nuclear hormone receptor | P37231 | PPARG_HUMAN | Details |
| Diseases ID | DO ID | Disease Name | Definition | Class |
|---|