Repositioning Candidate Details
| Candidate ID: | R0561 |
| Source ID: | DB02342 |
| Source Type: | investigational |
| Compound Type: | small molecule |
| Compound Name: | 2-Methoxyestradiol |
| Synonyms: | 2-Hydroxyestradiol 2-methyl ether; 2-Hydroxyestradol 2-methyl ether; 2-ME2; 2-methoxy-17β-estradiol; 2-Methoxyestradiol-17beta; 2ME2 |
| Molecular Formula: | C19H26O3 |
| SMILES: | [H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C(OC)=C3 |
| Structure: |
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| DrugBank Description: | 2-Methoxyestradiol (2ME2) is a drug that prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis). It has undergone Phase 1 clinical trials against breast cancers and preclinical studies suggest that 2ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis. |
| CAS Number: | 362-07-2 |
| Molecular Weight: | 302.4079 |
| DrugBank Indication: | For the treatment of breast cancer and inflammatory diseases such as rheumatoid arthritis. |
| DrugBank Pharmacology: | 2-Methoxyestradiol belongs to the family of drugs called angiogenesis inhibitors. It also acts as a vasodilator. |
| DrugBank MoA: | 2-Methoxyestradiol is an angiogenesis inhibitor, and has been shown to attack both tumor cells and their blood supply in preclinical testing. 2-methoxyestradiol is a naturally occurring estrogen metabolite but has no undesired estrogenic activity. |
| Targets: | Hypoxia-inducible factor 1-alpha; Catechol O-methyltransferase; Cytochrome P450 1A1; Cytochrome P450 1B1; Cytochrome P450 19A1 |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I15 | 1290 | Bone disease | A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function. http://en.wikipedia.org/wiki/Bone_disease | disease of anatomical entity/ musculoskeletal system disease/connective tissue disease | Details |