Repositioning Candidate Details
| Candidate ID: | R0569 |
| Source ID: | DB02703 |
| Source Type: | approved; investigational |
| Compound Type: | small molecule |
| Compound Name: | Fusidic acid |
| Synonyms: | Fucidate; Fucidin acid; Fusidate; Fusidic acid; Fusidine; Ramycin |
| Molecular Formula: | C31H48O6 |
| SMILES: | [H][C@@]12C[C@@H](O)[C@@]3([H])[C@@]4(C)CC[C@@H](O)[C@@H](C)[C@]4([H])CC[C@]3(C)[C@@]1(C)C[C@H](OC(C)=O)\C2=C(\CCC=C(C)C)C(O)=O |
| Structure: |
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| DrugBank Description: | An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed) It acts by inhibiting translocation during protein synthesis. It is often used topically in creams and eyedrops but is available in systemic formulations including tablets and injections. |
| CAS Number: | 6990-06-3 |
| Molecular Weight: | 516.7092 |
| DrugBank Indication: | For the treatment of bacterial infections. |
| DrugBank Pharmacology: | Fusidic acid is a bacteriostatic antibiotic and helps prevent bacterial growth while the immune system clears the infection. |
| DrugBank MoA: | Fusidic acid works by interfering with bacterial protein synthesis, specifically by preventing the translocation of the elongation factor G (EF-G) from the ribosome. It also can inhibit chloramphenicol acetyltransferase enzymes. |
| Targets: | Elongation factor G inhibitor; Chloramphenicol acetyltransferase inhibitor; Chloramphenicol acetyltransferase 3 inhibitor |
| Inclusion Criteria: | Indication associated |
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