Repositioning Candidate Details
| Candidate ID: | R0619 |
| Source ID: | DB04831 |
| Source Type: | withdrawn |
| Compound Type: | small molecule |
| Compound Name: | Tienilic acid |
| Synonyms: | (2,3-Dichloro-4-(2-thenoyl)phenoxy)acetic acid; (2,3-Dichloro-4-(2-thiophenecarbonyl)phenoxy)acetic acid; 4-(2-Thienylketo)-2,3-dichlorophenoxyacetic acid; Thienylic acid; Ticrynafen; Tienilic acid |
| Molecular Formula: | C13H8Cl2O4S |
| SMILES: | OC(=O)COC1=C(Cl)C(Cl)=C(C=C1)C(=O)C1=CC=CS1 |
| Structure: |
|
| DrugBank Description: | Tienilic acid, or ticrynafen, is a diuretic drug with uric acid-lowering action which was marketed for the treatment of hypertension. It was withdrawn in 1982 after case reports in the United States suggested a link between ticrynafen and hepatitis. (Manier et al., 1982) |
| CAS Number: | 40180-04-9 |
| Molecular Weight: | 331.171 |
| DrugBank Indication: | For the treatment of hypertension. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | -- |
| Targets: | -- |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I12 | 10763 | Hypertension | An artery disease characterized by chronic elevated blood pressure in the arteries. https://en.wikipedia.org/wiki/Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/24352797 | disease of anatomical entity/ cardiovascular system disease/vascular disease/ artery disease | Details |