Repositioning Candidate Details
| Candidate ID: | R0634 |
| Source ID: | DB04873 |
| Source Type: | investigational |
| Compound Type: | small molecule |
| Compound Name: | Piboserod |
| Synonyms: | Piboserod |
| Molecular Formula: | C22H31N3O2 |
| SMILES: | CCCCN1CCC(CNC(=O)C2=C3OCCCN3C3=CC=CC=C23)CC1 |
| Structure: |
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| DrugBank Description: | Piboserod (SB 207266) is a selective 5-HT(4) receptor antagonist. |
| CAS Number: | 152811-62-6 |
| Molecular Weight: | 369.5004 |
| DrugBank Indication: | For the treatment of atrial fibrillation and irritable bowel syndrome (IBS). |
| DrugBank Pharmacology: | GlaxoSmithKline was investigating piboserod, a 5HT4 antagonist, for the treatment of atrial fibrillation. Phase II trials were ongoing in March 2004, but by December of that year, development had been discontinued. Piboserod had previously being investigated for the treatment of irritable bowel syndrome (IBS), but development for this indication was terminated in 1999. |
| DrugBank MoA: | Piboserod appears to act as a specific antagonist of one of the receptors for 5-hydroxytryptamine, the 5-HT4 receptor. The 5-HT4 receptor antagonists are thought to antagonize both the ability of serotonin to sensitize the peristaltic reflex and 5-HT-induced defecation, at least in animal studies. As 5-HT4 receptors are present in human atrial cells and when stimulated may cause atrial arrhythmias, piboserod was under investigation in clinical trials for atrial fibrillation. |
| Targets: | 5-hydroxytryptamine receptor 4 |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I08 | 114 | Cardiovascular system disease | A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. http://en.wikipedia.org/wiki/Circulatory_system | disease of anatomical entity | Details |
| I11 | 5295 | Intestinal disease | A gastrointestinal system disease that is located_in the intestine. http://en.wikipedia.org/wiki/Human_gastrointestinal_tract | disease of anatomical entity/gastrointestinal system disease | Details |