Repositioning Candidate Details
| Candidate ID: | R0640 |
| Source ID: | DB04889 |
| Source Type: | investigational |
| Compound Type: | small molecule |
| Compound Name: | Bicifadine |
| Synonyms: | Bicifadine |
| Molecular Formula: | C12H15N |
| SMILES: | CC1=CC=C(C=C1)C12CC1CNC2 |
| Structure: |
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| DrugBank Description: | Bicifadine (DOV-220075) is a nonopioid analgesic. It is an inhibitor of both the norepinephrine and serotonin transporters and an NMDA antagonist with a non-narcotic profile. Bicifadine was shown to have potent analgesic activity in vivo and was chosen for further development for the treatment of pain. |
| CAS Number: | 71195-57-8 |
| Molecular Weight: | 173.2542 |
| DrugBank Indication: | For the treatment of pain. |
| DrugBank Pharmacology: | Bicifadine is a chemically distinct molecule with a unique profile of pharmacological activity. Its primary pharmacological action is to enhance and prolong the actions of norepinephrine and serotonin by inhibiting the transport proteins that terminate the physiological actions of the two biogenic amines. Bicifadine is not a narcotic and is well-tolerated and, in preclinical studies, has been shown not to act at any opiate receptor. Bicifadine does not exhibit any anti-inflammatory activity and does not inhibit prostaglandin synthetase in vitro. |
| DrugBank MoA: | Preclinical studies and clinical trials indicate that bicifadine's analgesic properties result through the enhancement and prolongation of norepinephrine and serotonin actions, however other actions may be involved. |
| Targets: | Sodium-dependent noradrenaline transporter; Sodium-dependent serotonin transporter; Dopamine D2 receptor |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class |
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