Repositioning Candidate Details
| Candidate ID: | R0646 |
| Source ID: | DB04918 |
| Source Type: | approved; investigational |
| Compound Type: | small molecule |
| Compound Name: | Ceftobiprole |
| Synonyms: | -- |
| Molecular Formula: | C20H22N8O6S2 |
| SMILES: | [H][C@@]1(NC(=O)C(=N/O)\C2=NSC(N)=N2)C(=O)N2C(C(O)=O)=C(CS[C@]12[H])\C=C1/CCN(C1=O)[C@]1([H])CCNC1 |
| Structure: |
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| DrugBank Description: | Ceftobiprole is a cephalosporin antibiotic with activity against methicillin-resistant <i>Staphylococcus aureus</i>. It was discovered by Basilea Pharmaceutica and is being developed by Johnson & Johnson Pharmaceutical Research and Development. Ceftobiprole is the first cephalosporin to demonstrate clinical efficacy in patients with infections due to methicillin-resistant staphylococci and, if approved by regulatory authorities, is expected to be a useful addition to the armamentarium of agents for the treatment of complicated skin infections and pneumonia. |
| CAS Number: | 209467-52-7 |
| Molecular Weight: | 534.57 |
| DrugBank Indication: | For the treatment of serious bacterial infections in hospitalised patients. |
| DrugBank Pharmacology: | Ceftobiprole, a cephalosporin antibiotic, is active against methicillin-resistant <i>Staphylococcus aureus</i>. |
| DrugBank MoA: | Cephalosporins, such as ceftobiprole, are bactericidal and have the same mode of action as other beta-lactam antibiotics (such as penicillins). Cephalosporins disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The final transpeptidation step in the synthesis of the peptidoglycan is facilitated by transpeptidases known as penicillin binding proteins (PBPs). PBPs bind to the D-Ala-D-Ala at the end of muropeptides (peptidoglycan precursors) to crosslink the peptidoglycan. Beta-lactam antibiotics mimic this site and competitively inhibit PBP crosslinking of peptidoglycan. |
| Targets: | MecA; Penicillin-binding protein 2x; Peptidoglycan synthase FtsI |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I01 | 552 | Pneumonia | A lung disease that involves lung parenchyma or alveolar inflammation and abnormal alveolar filling with fluid (consolidation and exudation). It results from a variety of causes including infection with bacteria, viruses, fungi or parasites, and chemical or physical injury to the lungs. It is accompanied by fever, chills, cough, and difficulty in breathing. http://en.wikipedia.org/wiki/Pneumonia | disease of anatomical entity/respiratory system disease/ lower respiratory tract disease/lung disease | Details |