Repositioning Candidate Details
| Candidate ID: | R0659 |
| Source ID: | DB04952 |
| Source Type: | investigational |
| Compound Type: | small molecule |
| Compound Name: | Ramoplanin |
| Synonyms: | Ramoplanin |
| Molecular Formula: | C119H154ClN21O40 |
| SMILES: | NCCC[C@H]1NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@H]([C@@H](O)C)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H]([C@@H](C)O)NC(=O)[C@@H](CCCN)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)\C=C/C=C\CC(C)C)[C@@H](OC(=O)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H]([C@@H](C)O)NC(=O)[C@@H](NC1=O)C1=CC=C(C=C1)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O)C1=CC=C(O)C=C1)C1=CC(Cl)=C(O)C=C1)C(N)=O)C1=CC=C(O)C=C1)C1=CC=C(O)C=C1)C1=CC=C(O)C=C1 |
| Structure: |
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| DrugBank Description: | Ramoplanin is a novel glycolipodepsipeptide antibiotic under development for the treatment of CDAD. |
| CAS Number: | 76168-82-6 |
| Molecular Weight: | 2554.066 |
| DrugBank Indication: | For the treatment of bacterial infections. |
| DrugBank Pharmacology: | Ramoplanin represents a new class of antibiotics with a novel mechanism of action that is highly effective against <i>Staphylococci</i>. |
| DrugBank MoA: | Ramoplanin is the first in a new class of antimicrobials to reach clinical trials. It is a glycolipodepsipeptide produced by the fermentation of <i>Actinoplanes spp.</i>. Ramoplanin blocks bacterial cell wall biosynthesis by interfering with peptidoglycan production. Ramoplanin inhibits the N-acetylglucosaminyltransferase-catalysed conversion of lipid intermediate I to lipid intermediate II, a step that occurs before the transglycosylation and transpeptidation reactions. Ramoplanin’s mechanism of action is distinct from that of glycopeptides. Unlike glycopeptides, ramoplanin does not complex with the D-Ala–D-Ala sequence of cell wall precursors. |
| Targets: | -- |
| Inclusion Criteria: | Indication associated |
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