Repositioning Candidate Details
| Candidate ID: | R0662 |
| Source ID: | DB04957 |
| Source Type: | investigational |
| Compound Type: | small molecule |
| Compound Name: | Azimilide |
| Synonyms: | Azimilide |
| Molecular Formula: | C23H28ClN5O3 |
| SMILES: | CN1CCN(CCCCN2C(=O)CN(N=CC3=CC=C(O3)C3=CC=C(Cl)C=C3)C2=O)CC1 |
| Structure: |
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| DrugBank Description: | Azimilide is an investigational class III anti-arrhythmic drug that blocks fast and slow components of the delayed rectifier cardiac potassium channels. It is not approved for use in any country, but is currently in clinical trials in the United States. |
| CAS Number: | 149908-53-2 |
| Molecular Weight: | 457.96 |
| DrugBank Indication: | Investigated for use/treatment in arrhythmia and atrial fibrillation. |
| DrugBank Pharmacology: | Azimilide is a new class III anti-arrhythmic agent. It is distinguished by a relative lack of reverse use-dependence, excellent oral absorption, no need for dose titration, an option for out-patient initiation, no need for adjustment associated with renal or liver failure and a lack of interaction with warfarin or digoxin. It carries some risk of torsade de pointes and rarely, neutropoenia. |
| DrugBank MoA: | The mechanism of action of azimilide is to block both the slowly conducting (I(Ks)) and rapidly conducting (I(Kr)) rectifier potassium currents in cardiac cells. This differs from other class III agents that block I(Kr) exclusively or in combination with sodium, calcium, or transient outward (I(to)) potassium current channels. It also has blocking effects on sodium (I(Na)) and calcium currents (I(CaL)). Its effects on reentrant circuits in infarct border zones causing ventricular tachyarrhythmias are unknown. |
| Targets: | Potassium voltage-gated channel subfamily E member 1; Potassium voltage-gated channel subfamily KQT member 1; Potassium voltage-gated channel subfamily H member 2 |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I08 | 114 | Cardiovascular system disease | A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. http://en.wikipedia.org/wiki/Circulatory_system | disease of anatomical entity | Details |