Repositioning Candidate Details
| Candidate ID: | R0675 |
| Source ID: | DB05004 |
| Source Type: | investigational |
| Compound Type: | small molecule |
| Compound Name: | Peptide YY (3-36) |
| Synonyms: | Pyy (3-36) peptide; PYY 3-36; PYY(3-36); PYY3-36 |
| Molecular Formula: | -- |
| SMILES: | -- |
| DrugBank Description: | Peptide YY (3-36), a synthetic human PYY 3-36, is a compound being evaluated for the treatment of obesity. It reduces appetite and increases satiety in obese patients. |
| CAS Number: | 123583-37-9 |
| Molecular Weight: | |
| DrugBank Indication: | Investigated for use/treatment in metabolic disease and obesity. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | PYY 3-36 acts via the presynaptic Y2 receptor in the ARC. It decreases neuropeptide Y (NPY) release from static hypothalamic explants and thus acts to decrease food intake. |
| Targets: | Neuropeptide Y receptor type 2; Neuropeptide Y receptor type 1; Neuropeptide Y receptor type 5; Neuropeptide Y receptor type 4 |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I14 | 9970 | Obesity | An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. https://en.wikipedia.org/wiki/Obesity | disease of metabolism/acquired metabolic disease/ nutrition disease/overnutrition | Details |