Repositioning Candidate Details
| Candidate ID: | R0712 |
| Source ID: | DB05132 |
| Source Type: | investigational |
| Compound Type: | small molecule |
| Compound Name: | ND1251 |
| Synonyms: | -- |
| Molecular Formula: | -- |
| SMILES: | -- |
| DrugBank Description: | ND1251 is an orally active phosphodiesterase-4 (PDE4) inhibitor, a mechanism clinically proven to play a role in alleviating symptoms of depression. ND1251 is a very potent compound with a large safety margin. ND1251 may also have applications in other disorders, such as Alzheimer's disease, mild cognitive impairment, multiple sclerosis and certain respiratory diseases. |
| CAS Number: | -- |
| Molecular Weight: | |
| DrugBank Indication: | Investigated for use/treatment in depression. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | ND1251 works by inhibiting the enzyme phophodiesterase. This increases the intracellular concentration of cAMP, a second messenger, which regulates enzymes involved in energy metabolism and cell division. This appears to play an important role in brain function. |
| Targets: | -- |
| Inclusion Criteria: | Indication associated |
