Repositioning Candidate Details
| Candidate ID: | R0757 |
| Source ID: | DB05266 |
| Source Type: | investigational |
| Compound Type: | small molecule |
| Compound Name: | Ibudilast |
| Synonyms: | Ibudilast |
| Molecular Formula: | C14H18N2O |
| SMILES: | CC(C)C(=O)C1=C2C=CC=CN2N=C1C(C)C |
| Structure: |
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| DrugBank Description: | Ibudilast is an anti-inflammatory and neuroprotective oral agent which shows an excellent safety profile at 60 mg/day and provides significantly prolonged time-to-first relapse and attenuated brain volume shrinkage in patients with relapsing-remitting (RR) and/or secondary progressive (SP) multiple sclerosis (MS). Ibudilast is currently in development in the U.S. (codes: AV-411 or MN-166), but is approved for use as an antiinflammatory in Japan. |
| CAS Number: | 50847-11-5 |
| Molecular Weight: | 230.3055 |
| DrugBank Indication: | For the treatment of multiple sclerosis, asthma, and cerebrovascular disease. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | Ibudilast has mechanisms that include anti-inflammatory effects, such as phosphodiesterase inhibition, and neuroprotective effects, such as inhibition of synthesis and reduction in reactive oxygen species. |
| Targets: | cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor; cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor; cAMP-specific 3',5'-cyclic phosphodiesterase 4C inhibitor; cAMP-specific 3',5'-cyclic phosphodiesterase 4D inhibitor; cGMP-inhibited 3',5'-cyclic phosphodiesterase A inhibitor |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I16 | 6713 | Cerebrovascular disease | An vascular disease that is characterized by dysfunction of the blood vessels supplying the brain. http://en.wikipedia.org/wiki/Cerebrovascular_disease, http://www.ncbi.nlm.nih.gov/books/NBK378/ | disease of anatomical entity/ cardiovascular system disease/ vascular disease/cerebrovascular disease | Details |