Repositioning Candidate Details
| Candidate ID: | R0758 |
| Source ID: | DB05273 |
| Source Type: | approved; investigational |
| Compound Type: | small molecule |
| Compound Name: | Samarium (153Sm) lexidronam |
| Synonyms: | 153SM-EDTMP; Samarium (153 Sm) lexidronam; Samarium (153Sm) lexidronam; Samarium Sm-153 lexidronam; Samarium-153 lexidronam; Samarium-153-EDTMP |
| Molecular Formula: | C6H17N2O12P4Sm |
| SMILES: | [153Sm+3].OP(O)(=O)CN(CCN(CP(O)([O-])=O)CP(O)([O-])=O)CP(O)([O-])=O |
| Structure: |
|
| DrugBank Description: | Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium Sm 153 lexidronam is used to help relieve the bone pain that may occur with certain kinds of cancer. The radioactive samarium is taken up in the bone cancer area and gives off radiation that helps provide relief of pain. |
| CAS Number: | 122575-21-7 |
| Molecular Weight: | 586.021 |
| DrugBank Indication: | Investigated for use/treatment in bone metastases, multiple myeloma, prostate cancer, and rheumatoid arthritis. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | Samarium Sm 153 lexidronam targets the sites of new bone formation, concentrating in regions of the bone that have been invaded with metastatic tumor. The drug goes to the source of cancer bone pain and irradiates the osteoblastic tumor sites resulting in relief of pain. The onset of pain relief was experienced as early as one week in the majority of patients. |
| Targets: | -- |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I15 | 1290 | Bone disease | A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function. http://en.wikipedia.org/wiki/Bone_disease | disease of anatomical entity/ musculoskeletal system disease/connective tissue disease | Details |