Repositioning Candidate Details
| Candidate ID: | R0778 |
| Source ID: | DB05383 |
| Source Type: | investigational |
| Compound Type: | small molecule |
| Compound Name: | Pimagedine |
| Synonyms: | Aminate base; Aminoguanidine; Guanyl hydrazine; Hydrazinecarboximidamide; Monoaminoguanidine; Pimagedine |
| Molecular Formula: | CH6N4 |
| SMILES: | NNC(N)=N |
| Structure: |
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| DrugBank Description: | Pimagedine has been developed by Synvista Therapeutics, Inc for the treatment of diabetic kidney disease. It is an advanced glycation end product inhibitor which manages diabetic nephropathy, either alone or in combination with other therapies. It is beneficial in treating patients with diabetic nephropathy. |
| CAS Number: | 79-17-4 |
| Molecular Weight: | 74.0851 |
| DrugBank Indication: | Investigated for use/treatment in diabetic kidney disease. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | Pimagedine reportedly inhibits the formation of glycosylated proteins (advanced glycosylation end-products) and has other actions including inhibition of aldose reductase. |
| Targets: | Nitric oxide synthase, inducible inhibitor; Aldose reductase; Metalloproteinase inhibitor 3 |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I05 | 9352 | Type 2 diabetes mellitus | A diabetes that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. http://en.wikipedia.org/wiki/Diabetes, http://en.wikipedia.org/wiki/Diabetes_mellitus_type_2 | disease of metabolism/inherited metabolic disorder/ carbohydrate metabolic disorder/glucose metabolism disease/diabetes/ diabetes mellitus | Details |