Repositioning Candidate Details
| Candidate ID: | R0782 |
| Source ID: | DB05395 |
| Source Type: | investigational |
| Compound Type: | small molecule |
| Compound Name: | Amibegron |
| Synonyms: | Amibegron |
| Molecular Formula: | C22H26ClNO4 |
| SMILES: | [H][C@](O)(CN[C@@]1([H])CCC2=C(C1)C=C(OCC(=O)OCC)C=C2)C1=CC(Cl)=CC=C1 |
| Structure: |
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| DrugBank Description: | Amibegron is an agonist for atypical beta3-adrenoceptors which inhibits intestinal motility. |
| CAS Number: | 121524-08-1 |
| Molecular Weight: | 403.9 |
| DrugBank Indication: | Investigated for use/treatment in depression, irritable bowel syndrome (IBS), and obesity. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | SR 58611 has positive chronotropic effect which is mainly of peripheral origin and can be attributed to a baroreceptor-mediated reflex due to the beta3-adrenoceptor mediated vasodilation with an increase in sympathetic tone and a reduction in vagal tone to the heart. |
| Targets: | Beta-3 adrenergic receptor |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I17 | 1596 | Mental depression | Mental depression | disease of mental health/ cognitive disorder/ mood disorder | Details |
| I11 | 5295 | Intestinal disease | A gastrointestinal system disease that is located_in the intestine. http://en.wikipedia.org/wiki/Human_gastrointestinal_tract | disease of anatomical entity/gastrointestinal system disease | Details |
| I14 | 9970 | Obesity | An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. https://en.wikipedia.org/wiki/Obesity | disease of metabolism/acquired metabolic disease/ nutrition disease/overnutrition | Details |