Repositioning Candidate Details
| Candidate ID: | R0785 |
| Source ID: | DB05409 |
| Source Type: | investigational |
| Compound Type: | small molecule |
| Compound Name: | NCX 701 |
| Synonyms: | -- |
| Molecular Formula: | C12H14N2O6 |
| SMILES: | CC(=O)NC1=CC=C(OC(=O)CCCO[N+]([O-])=O)C=C1 |
| Structure: |
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| DrugBank Description: | Nitroparacetamol (NCX-701) is a newly synthesized nitric oxide-releasing derivative of paracetamol. |
| CAS Number: | -- |
| Molecular Weight: | 282.2494 |
| DrugBank Indication: | Investigated for use/treatment in pain (acute or chronic). |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | NCX-701 (nitroparacetamol) is a NO-releasing derivative of paracetamol (acetaminophen) that has shown potent antinociceptive and anti-inflammatory properties. NCX-701 induces a potent antinociceptive effect by a mechanism different from and complementary to that of paracetamol, and its action is mainly located within the spinal cord in monoarthritic animals. |
| Targets: | -- |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Diseases ID | DO ID | Disease Name | Definition | Class |
|---|