Repositioning Candidate Details
| Candidate ID: | R0793 |
| Source ID: | DB05423 |
| Source Type: | investigational |
| Compound Type: | small molecule |
| Compound Name: | ORG-34517 |
| Synonyms: | -- |
| Molecular Formula: | C28H30O4 |
| SMILES: | [H][C@@]12CC[C@@](O)(C#CC)[C@@]1(C)C[C@H](C1=CC=C3OCOC3=C1)C1=C3CCC(=O)C=C3CC[C@@]21[H] |
| Structure: |
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| DrugBank Description: | ORG-34517 is currently under investigation by Organon for the treatment of depression. It has potential to treat a number of diseases such as Cushing’s disease, hypertension, diabetes, glaucoma etc, in which the activity of metabolites corticosterone and cortisol is high. |
| CAS Number: | 189035-07-2 |
| Molecular Weight: | 430.544 |
| DrugBank Indication: | Investigated for use/treatment in depression. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | Org-34517 is a glucocorticoid antagonist which may have a potential in a number of diseases where there is excess corticosterone/cortisol activity. The drug acts by normalizing hyperactivity in the hypothalamus-pituitary-adrenal (HPA) axis. |
| Targets: | Glucocorticoid receptor |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I17 | 1596 | Mental depression | Mental depression | disease of mental health/ cognitive disorder/ mood disorder | Details |
| I12 | 10763 | Hypertension | An artery disease characterized by chronic elevated blood pressure in the arteries. https://en.wikipedia.org/wiki/Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/24352797 | disease of anatomical entity/ cardiovascular system disease/vascular disease/ artery disease | Details |