Repositioning Candidate Details
| Candidate ID: | R0080 |
| Source ID: | DB00212 |
| Source Type: | experimental |
| Compound Type: | small molecule |
| Compound Name: | Remikiren |
| Synonyms: | Remikiren |
| Molecular Formula: | C33H50N4O6S |
| SMILES: | CC(C)(C)S(=O)(=O)C[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)[C@@H](O)C1CC1 |
| Structure: |
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| DrugBank Description: | Remikiren is an orally active, high specificity renin inhibitor. |
| CAS Number: | 126222-34-2 |
| Molecular Weight: | 630.838 |
| DrugBank Indication: | For the treatment of hypertension and heart failure |
| DrugBank Pharmacology: | Remikiren is an orally available renin inhibitor with an established blood pressure-lowering effect in patients with essential hypertension. No data are available on the renal effects of remikiren in humans. In patients with essential hypertension, a single oral dose of remikiren can induce a renal vasodilation, without affecting the GFR and despite a significant decrease in blood pressure. This systemic and renal hemodynamic response is more pronounced in case of a more activated renin-angiotensin system. |
| DrugBank MoA: | Several in vivo experiments have shown that remikiren is specific for renin and does not decrease arterial pressure by an unrelated mechanism. |
| Targets: | Renin inhibitor |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I12 | 10763 | Hypertension | An artery disease characterized by chronic elevated blood pressure in the arteries. https://en.wikipedia.org/wiki/Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/24352797 | disease of anatomical entity/ cardiovascular system disease/vascular disease/ artery disease | Details |