Repositioning Candidate Details
| Candidate ID: | R0811 |
| Source ID: | DB05475 |
| Source Type: | investigational |
| Compound Type: | small molecule |
| Compound Name: | Golotimod |
| Synonyms: | Golotimod |
| Molecular Formula: | C16H19N3O5 |
| SMILES: | N[C@H](CCC(=O)N[C@@H](CC1=CNC2=CC=CC=C12)C(O)=O)C(O)=O |
| Structure: |
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| DrugBank Description: | SCV-07 (g -D-glutamyl-L-tryptophan) is a novel synthetic dipeptide that acts broadly on the Toll-like receptor pathway. It has been shown to stimulate T-lymphocyte differentiation, macrocytic phagocytosis, and specific immune responses, and enhance IL-2 and INF-g production. Due to this preferential activation of Th1 cytokine production, SCV-07 may show utility in treatment of tuberculosis. It can be administered orally or subcutaneously. In independent studies, treatment of tuberculosis with SCV-07 improved clearance of mycobacteria, improved cavity healing, improvements in immune parameters and reduced symptoms (fever, weakness, sweating, dry cough, productive cough, dyspnea, chest pain, tachycardia) without any adverse local or general effects. SCV-07 has shown efficacy in treating various viral and bacterial infections. |
| CAS Number: | 229305-39-9 |
| Molecular Weight: | 333.3392 |
| DrugBank Indication: | Investigated for use/treatment in hepatitis (viral, C), infectious and parasitic disease (unspecified), and tuberculosis. |
| DrugBank Pharmacology: | SCV-07 (g -D-glutamyl-L-tryptophan) is a novel synthetic dipeptide that acts broadly on the Toll-like receptor pathway. It has been shown to stimulate T-lymphocyte differentiation, macrocytic phagocytosis, and specific immune responses, and enhance IL-2 and INF-g production. |
| DrugBank MoA: | SCV-07 (g -D-glutamyl-L-tryptophan) has broad effects on the Toll-like receptor (TLR) pathway. |
| Targets: | Toll-like receptor 2; Toll-like receptor 4; Toll-like receptor 7; Toll-like receptor 9 |
| Inclusion Criteria: | Target associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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