Repositioning Candidate Details
| Candidate ID: | R0084 |
| Source ID: | DB00217 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Bethanidine |
| Synonyms: | Betanidine; Bethanidine; N,N'-dimethyl-N''-(phenylmethyl)-guanidine |
| Molecular Formula: | C10H15N3 |
| SMILES: | CN\C(NCC1=CC=CC=C1)=N/C |
| Structure: |
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| DrugBank Description: | A guanidinium antihypertensive agent that acts by blocking adrenergic transmission. |
| CAS Number: | 55-73-2 |
| Molecular Weight: | 177.2462 |
| DrugBank Indication: | For the treatment of hypertension. |
| DrugBank Pharmacology: | Bethanidine is a guanidinium antihypertensive agent that acts by blocking adrenergic transmission. The precise mode of action is not clear. Although bethanidine may produce adverse effects, they are beneficial in severe hypertension and produce fewer side effects than guanethidine. |
| DrugBank MoA: | Bethanidine, a guanidine derivative, is a peripherally acting antiadrenergic agent which primarily acts as an alpha2a adrenergic agonist. Bethanidine effectively decreases blood pressure by suppressing renin secretion or interfering with function of the sympathetic nervous system. |
| Targets: | Alpha-2 adrenergic receptors agonist; ATP-sensitive inward rectifier potassium channel 1 inhibitor; Beta adrenergic receptor antagonist |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I12 | 10763 | Hypertension | An artery disease characterized by chronic elevated blood pressure in the arteries. https://en.wikipedia.org/wiki/Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/24352797 | disease of anatomical entity/ cardiovascular system disease/vascular disease/ artery disease | Details |