Repositioning Candidate Details
| Candidate ID: | R0847 |
| Source ID: | DB05678 |
| Source Type: | investigational |
| Compound Type: | small molecule |
| Compound Name: | SLx-4090 |
| Synonyms: | -- |
| Molecular Formula: | C31H25F3N2O4 |
| SMILES: | COC1=CC=CC(C(=O)NC2=CC3=C(CN(CC3)C(=O)OC3=CC=CC=C3)C=C2)=C1C1=CC=C(C=C1)C(F)(F)F |
| Structure: |
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| DrugBank Description: | SLx-4090 is a microsomal triglyceride transfer protein (MTTP) inhibitor potentially for the treatment of type 2 diabetes. |
| CAS Number: | 913541-47-6 |
| Molecular Weight: | 546.546 |
| DrugBank Indication: | Investigated for use/treatment in hyperlipidemia. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | SLx-4090 inhibits Microsomal Triglyceride Transfer Protein (MTP). It acts selectively in the enterocytes lining the gastrointestinal tract, preventing the formation of chylomicrons which are used to transport triglyceride (TG) and cholesterol into the systemic circulation. |
| Targets: | Microsomal triglyceride transfer protein large subunit inhibitor |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I05 | 9352 | Type 2 diabetes mellitus | A diabetes that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. http://en.wikipedia.org/wiki/Diabetes, http://en.wikipedia.org/wiki/Diabetes_mellitus_type_2 | disease of metabolism/inherited metabolic disorder/ carbohydrate metabolic disorder/glucose metabolism disease/diabetes/ diabetes mellitus | Details |