Repositioning Candidate Details
| Candidate ID: | R0087 |
| Source ID: | DB00226 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Guanadrel |
| Synonyms: | -- |
| Molecular Formula: | C10H19N3O2 |
| SMILES: | NC(N)=NCC1COC2(CCCCC2)O1 |
| Structure: |
|
| DrugBank Description: | Guanadrel is an antihypertensive agent and postganglionic adrenergic blocking agent. |
| CAS Number: | 40580-59-4 |
| Molecular Weight: | 213.2768 |
| DrugBank Indication: | Used to treat and control hypertension. |
| DrugBank Pharmacology: | High blood pressure adds to the work load of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled. Guanadrel works by controlling nerve impulses along certain nerve pathways. As a result, it relaxes the blood vessels so that blood passes through them more easily. This helps to lower blood pressure. |
| DrugBank MoA: | Guanadrel is an adrenergic neuron inhibitor that slowly displaces norepinephrine from its storage in nerve endings. It blocks the release of norepinephrine in response to the sympathetic nerve stimulation, leading to reduced arteriolar vasoconstriction, especially the reflex increase in sympathetic tone that occurs with a change in position. |
| Targets: | Sodium-dependent noradrenaline transporter partial agonist |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I16 | 6713 | Cerebrovascular disease | An vascular disease that is characterized by dysfunction of the blood vessels supplying the brain. http://en.wikipedia.org/wiki/Cerebrovascular_disease, http://www.ncbi.nlm.nih.gov/books/NBK378/ | disease of anatomical entity/ cardiovascular system disease/ vascular disease/cerebrovascular disease | Details |
| I12 | 10763 | Hypertension | An artery disease characterized by chronic elevated blood pressure in the arteries. https://en.wikipedia.org/wiki/Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/24352797 | disease of anatomical entity/ cardiovascular system disease/vascular disease/ artery disease | Details |