Repositioning Candidate Details
| Candidate ID: | R0898 |
| Source ID: | DB05906 |
| Source Type: | investigational |
| Compound Type: | biotech |
| Compound Name: | CCR5 mAb |
| Synonyms: | -- |
| Molecular Formula: | -- |
| SMILES: | -- |
| DrugBank Description: | CCR5 mAb is a fully human monoclonal antibody that specifically recognizes and binds the chemokine receptor CCR5, which is known to be a key facilitator of infection with human immunodeficiency virus (HIV-1). It was generated by HGS using the Abgenix XenoMouse technology. |
| CAS Number: | -- |
| Molecular Weight: | |
| DrugBank Indication: | Investigated for use/treatment in HIV infection. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | The chemokine receptor CCR5 provides a portal of entry for HIV-1 and serves a target for potential new antiretroviral therapies. CCR5 monoclonal antibodies (mAb) and small-molecule CCR5 antagonists potently block HIV-1 entry in vitro, and controlled clinical trials have provided initial proof-of-concept for this mode of therapy. |
| Targets: | C-C chemokine receptor type 5 |
| Inclusion Criteria: | Target associated |
