Repositioning Candidate Details
| Candidate ID: | R0902 |
| Source ID: | DB05943 |
| Source Type: | investigational |
| Compound Type: | small molecule |
| Compound Name: | Resatorvid |
| Synonyms: | Resatorvid |
| Molecular Formula: | C15H17ClFNO4S |
| SMILES: | [H][C@]1(CCCC=C1C(=O)OCC)S(=O)(=O)NC1=C(Cl)C=C(F)C=C1 |
| Structure: |
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| DrugBank Description: | Resatorvid is an investigational compound designed for the treatment of severe sepsis. |
| CAS Number: | 243984-11-4 |
| Molecular Weight: | 361.81 |
| DrugBank Indication: | Investigated for use/treatment in sepsis and septicemia. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | TAK-242 suppresses production of inflammatory mediators such as cytokine by inhibiting the signal transduction through Toll-like receptor 4 (TLR4) which is one of the receptors recognizing the bacterial components. |
| Targets: | Cytokine receptor common subunit beta; Cytokine receptor common subunit gamma |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Diseases ID | DO ID | Disease Name | Definition | Class |
|---|