Repositioning Candidate Details
| Candidate ID: | R0913 |
| Source ID: | DB05993 |
| Source Type: | investigational |
| Compound Type: | small molecule |
| Compound Name: | PRX-07034 |
| Synonyms: | -- |
| Molecular Formula: | C21H29Cl2N3O4S |
| SMILES: | Cl.COC1=C(OC)C(=CC(Cl)=C1)C(C)NC1=CC(=CC=C1S(C)(=O)=O)N1CCNCC1 |
| Structure: |
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| DrugBank Description: | -- |
| CAS Number: | 903580-39-2 |
| Molecular Weight: | 490.44 |
| DrugBank Indication: | Investigated for use/treatment in alzheimer's disease, obesity, and schizophrenia and schizoaffective disorders. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | PRX-07034 is a novel, highly selective, small-molecule antagonist of a specific G-protein coupled receptor (GPCR) known as 5-HT6 being developed for the treatment of obesity, Alzheimer's disease and cognitive impairment associated with schizophrenia. PRX-07034 has also been shown to enhance cognitive function in preclinical animal models of memory impairment through a dual mechanism of action.It has an effect on both the acetylcholine and glutamate neurotransmitter systems in the brain, which makes it a potentially complementary therapy to cholinesterase inhibitors, a class of drugs approved for the treatment of Alzheimer's disease. |
| Targets: | 5-hydroxytryptamine receptor 6 |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I14 | 9970 | Obesity | An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. https://en.wikipedia.org/wiki/Obesity | disease of metabolism/acquired metabolic disease/ nutrition disease/overnutrition | Details |