Repositioning Candidate Details
| Candidate ID: | R0934 |
| Source ID: | DB06156 |
| Source Type: | investigational |
| Compound Type: | small molecule |
| Compound Name: | Tesofensine |
| Synonyms: | Tesofensine |
| Molecular Formula: | C17H23Cl2NO |
| SMILES: | CCOC[C@H]1[C@H]2CC[C@@H](C[C@@H]1C1=CC(Cl)=C(Cl)C=C1)N2C |
| Structure: |
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| DrugBank Description: | -- |
| CAS Number: | 195875-84-4 |
| Molecular Weight: | 328.28 |
| DrugBank Indication: | Investigated for use/treatment in alzheimer's disease, parkinson's disease, and obesity. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | Tesofensine is a Serotonin-norepinephrine-dopamine-reuptake-inhibitor (SNDRI). SNDRIs are a class of psychoactive antidepressants. They act upon neurotransmitters in the brain, namely, serotonin, norepinephrine and dopamine. These three biogenic monoamines are associated with depression and increasing the availability in the brain is one method used to treat the condition. |
| Targets: | Sodium-dependent serotonin transporter; Sodium-dependent noradrenaline transporter; Sodium-dependent dopamine transporter |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I17 | 1596 | Mental depression | Mental depression | disease of mental health/ cognitive disorder/ mood disorder | Details |
| I14 | 9970 | Obesity | An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. https://en.wikipedia.org/wiki/Obesity | disease of metabolism/acquired metabolic disease/ nutrition disease/overnutrition | Details |