Repositioning Candidate Details
| Candidate ID: | R0954 |
| Source ID: | DB06245 |
| Source Type: | investigational |
| Compound Type: | biotech |
| Compound Name: | Lanoteplase |
| Synonyms: | Lanoteplase |
| Molecular Formula: | -- |
| SMILES: | -- |
| DrugBank Description: | -- |
| CAS Number: | 171870-23-8 |
| Molecular Weight: | |
| DrugBank Indication: | Investigated for use/treatment in myocardial infarction. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | Lanoteplase is a second generation derivative of alteplase, and a third generation recombinant plasminogen activator made from a deletion and point mutant of tissue type-plasminogen activator (t-PA). Lanoteplase has a longer half life than alteplase. Lanoteplase is a serine protease that binds to fibrin in a thrombus (blood clot)and cleaves the Arg-Val bond in plasminogen, producing active plasmin. Plasmin is an enzyme that degrades plasma proteins such as fibrin clots to clear blocked blood vessels that cause myocardial infarction (heart attack) or stroke. |
| Targets: | Urokinase plasminogen activator surface receptor; Fibrinogen alpha chain; Kallikrein-1; Laminin subunit alpha-5; Coagulation factor X; Fibronectin; Plasminogen activator inhibitor 2; Tetranectin; Keratin, type II cytoskeletal 8; Annexin A2; Laminin subunit beta-1; Laminin subunit gamma-1; Laminin subunit alpha-1; Calreticulin; Calnexin; Prolow-density lipoprotein receptor-related protein 1; Laminin subunit alpha-3 |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I08 | 114 | Cardiovascular system disease | A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. http://en.wikipedia.org/wiki/Circulatory_system | disease of anatomical entity | Details |
| I16 | 6713 | Cerebrovascular disease | An vascular disease that is characterized by dysfunction of the blood vessels supplying the brain. http://en.wikipedia.org/wiki/Cerebrovascular_disease, http://www.ncbi.nlm.nih.gov/books/NBK378/ | disease of anatomical entity/ cardiovascular system disease/ vascular disease/cerebrovascular disease | Details |