Repositioning Candidate Details
| Candidate ID: | R0957 |
| Source ID: | DB06249 |
| Source Type: | approved; investigational |
| Compound Type: | small molecule |
| Compound Name: | Arzoxifene |
| Synonyms: | Arzoxifene |
| Molecular Formula: | C28H29NO4S |
| SMILES: | COC1=CC=C(C=C1)C1=C(OC2=CC=C(OCCN3CCCCC3)C=C2)C2=C(S1)C=C(O)C=C2 |
| Structure: |
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| DrugBank Description: | -- |
| CAS Number: | 182133-25-1 |
| Molecular Weight: | 475.6 |
| DrugBank Indication: | Investigated for use/treatment in breast cancer, osteoporosis, and endometrial cancer. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | Arzoxifene is a selective estrogen receptor modulator (SERM) which antagonizes estrogen in mammary and uterine tissue, but acts as an estrogen receptor agonist in bone tissue. Arzoxifene reduces bone loss and risk of osteoperosis and decreases serum cholesterol. |
| Targets: | Estrogen receptor alpha; Estrogen receptor beta |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I15 | 1290 | Bone disease | A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function. http://en.wikipedia.org/wiki/Bone_disease | disease of anatomical entity/ musculoskeletal system disease/connective tissue disease | Details |