Repositioning Candidate Details
| Candidate ID: | R0959 |
| Source ID: | DB06253 |
| Source Type: | investigational |
| Compound Type: | small molecule |
| Compound Name: | Thioctic acid tromethamine |
| Synonyms: | (R)-5-(1,2-dithiolaln-3-yl)-pentanoic acid tromethamine; Thioctic acid tromethamine |
| Molecular Formula: | C12H25NO5S2 |
| SMILES: | NC(CO)(CO)CO.OC(=O)CCCC[C@@H]1CCSS1 |
| Structure: |
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| DrugBank Description: | A salt of alpha-lipoic acid and tromethamine; may be useful in treating vascular stress in patients with diabetes. |
| CAS Number: | 137314-40-0 |
| Molecular Weight: | 327.45 |
| DrugBank Indication: | Investigated for use/treatment in diabetes mellitus type 2, neuropathy (diabetic), and vascular diseases. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | -- |
| Targets: | -- |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I05 | 9352 | Type 2 diabetes mellitus | A diabetes that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. http://en.wikipedia.org/wiki/Diabetes, http://en.wikipedia.org/wiki/Diabetes_mellitus_type_2 | disease of metabolism/inherited metabolic disorder/ carbohydrate metabolic disorder/glucose metabolism disease/diabetes/ diabetes mellitus | Details |