Repositioning Candidate Details
| Candidate ID: | R0965 |
| Source ID: | DB06267 |
| Source Type: | approved; investigational |
| Compound Type: | small molecule |
| Compound Name: | Udenafil |
| Synonyms: | Udenafil |
| Molecular Formula: | C25H36N6O4S |
| SMILES: | CCCOC1=C(C=C(C=C1)S(=O)(=O)NCCC1CCCN1C)C1=NC(=O)C2=C(N1)C(CCC)=NN2C |
| Structure: |
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| DrugBank Description: | Udenafil is a new phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction (ED). It has been approved in South Korea and will be marketed under the brand name Zydena. It is not yet approved for use in the U.S., E.U., or Canada. |
| CAS Number: | 268203-93-6 |
| Molecular Weight: | 516.656 |
| DrugBank Indication: | Investigated for use/treatment in erectile dysfunction and hypertension. |
| DrugBank Pharmacology: | Udenafil is a potent selective phosphodiesterase type 5 (PDE5) inhibitor. |
| DrugBank MoA: | Udenafil inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by udenafil enhances erectile function by increasing the amount of cGMP. |
| Targets: | cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I12 | 10763 | Hypertension | An artery disease characterized by chronic elevated blood pressure in the arteries. https://en.wikipedia.org/wiki/Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/24352797 | disease of anatomical entity/ cardiovascular system disease/vascular disease/ artery disease | Details |