Repositioning Candidate Details
| Candidate ID: | R0987 |
| Source ID: | DB06345 |
| Source Type: | investigational |
| Compound Type: | small molecule |
| Compound Name: | AR-9281 |
| Synonyms: | APAU |
| Molecular Formula: | C18H29N3O2 |
| SMILES: | CC(=O)N1CCC(CC1)NC(=O)NC12CC3CC(CC(C3)C1)C2 |
| Structure: |
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| DrugBank Description: | AR-9281 inhibits soluble epoxide hydrolase. |
| CAS Number: | 913548-29-5 |
| Molecular Weight: | 319.449 |
| DrugBank Indication: | Investigated for use/treatment in hypertension. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | AR9281 inhibits soluble epoxide hydrolase (s-EH), an enzyme that plays a key role in the cytochrome P450 pathway of arachidonic acid metabolism. Nuclear factor alpha B (NF-alphaB) is a transcription factor implicated in cardiac hypertrophy, and can be anti or pro apoptotic under different conditions. Epoxyeicosatrienoic acids (EETs), a product of cytochrome P450 epoxygenase enzyme action, have a variety of anti-hypertensive and anti-inflammatory effects. EETs have a vasodilatory action similar to endothelium derived hyperpolarizing factor and may inhibit NF-alphaB through a currently unknown mechanism. The enzyme s-EH catalyzes the breakdown of EETs to dihydroxyeicosatrienoic acids. AR9281's inhibition of s-EH enhances EETs anti-hypertensive and anti-inflammatory activities by preventing their breakdown by s-EH, as well as inhibiting NF-alphaB. |
| Targets: | Bifunctional epoxide hydrolase 2 |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S11 | Anti-hypertensive | -- | angiotensin converting enzyme inhibitors (ACEi) ; angiotensin II receptor blockers (ARBs) | Captopril | Details |
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I12 | 10763 | Hypertension | An artery disease characterized by chronic elevated blood pressure in the arteries. https://en.wikipedia.org/wiki/Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/24352797 | disease of anatomical entity/ cardiovascular system disease/vascular disease/ artery disease | Details |