CMap Candidate Details

Structure:
CMap ID: C10146
Pert ID: BRD-K24496482
Compound Name: SB-590885
Targets: BRAF
MoA: RAF inhibitor
SMILES: CN(C)CCOC1=CC=C(C=C1)C2=NC(=C3C=CC4=C(CCC4=C3)N=O)C(=C5C=CNC=C5)N2
InchiKey: DPCXEUSDRQOOGZ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
92000 BRD-K24496482 A375 0.37 uM 24 h 0.0 0.0 0.0 0.26 0.94 0.28
92027 BRD-K24496482 BT20 3.33 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.18
92076 BRD-K24496482 HA1E 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92111 BRD-K24496482 HCC515 0.12 uM 24 h 0.21 0.89 0.02 -0.42 -1.41 2.02
92144 BRD-K24496482 HS578T 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92196 BRD-K24496482 HT29 0.04 uM 24 h 0.2 0.84 0.0 0.36 1.28 1.37
92240 BRD-K24496482 MCF10A 3.33 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92260 BRD-K24496482 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92296 BRD-K24496482 MDAMB231 1.11 uM 24 h 0.28 1.16 0.36 0.46 1.62 2.4
92349 BRD-K24496482 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92393 BRD-K24496482 SKBR3 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).