CMap Candidate Details

Structure:
CMap ID: C01015
Pert ID: BRD-A41519720
Compound Name: ezetimibe
Targets: NPC1L1
MoA: Cholesterol inhibitor; Niemann-Pick C1-like 1 protein antagonist
SMILES: OC(CC[C@@H]1[C@H](N(C1=O)c1ccc(F)cc1)c1ccc(O)cc1)c1ccc(F)cc1
InchiKey: OLNTVTPDXPETLC-OJVMETQDSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5399 BRD-A41519720 HA1E 10 uM 6 h 0.0 0.0 0.0 0.28 0.98 0.36
5517 BRD-A41519720 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.7
6070 BRD-A41519720 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6132 BRD-A41519720 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6463 BRD-A41519720 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37075 BRD-A41519720 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37235 BRD-A41519720 A549 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
37497 BRD-A41519720 ASC 10 uM 24 h 0.0 0.0 0.0 0.32 1.12 0.79
37820 BRD-A41519720 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38013 BRD-A41519720 HT29 10 uM 6 h 0.0 0.0 0.0 0.35 1.23 1.19
38347 BRD-A41519720 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38858 BRD-A41519720 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).