CMap Candidate Details

Structure:
CMap ID: C10182
Pert ID: BRD-K24576554
Compound Name: AT-9283
Targets: JAK2; JAK3; AURKA; AURKB
MoA: JAK inhibitor; FLT3 inhibitor; Mitotic inhibitor; Abl kinase inhibitor; Aurora kinase inhibitor; Protein kinase inhibitor
SMILES: O=C(NC1CC1)Nc1c[nH]nc1-c1nc2cc(CN3CCOCC3)ccc2[nH]1
InchiKey: LOLPPWBBNUVNQZ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
95490 BRD-K24576554 A549 1.11 uM 24 h 0.26 1.08 0.2 -0.23 -0.78 0.09
95632 BRD-K24576554 U2OS 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119397 BRD-K24576554 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119494 BRD-K24576554 HCC515 3.33 uM 24 h 0.0 0.0 0.0 0.25 0.9 0.21
119531 BRD-K24576554 HEPG2 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121396 BRD-K24576554 HA1E 1.11 uM 24 h 0.0 0.0 0.0 0.23 0.83 0.11
121430 BRD-K24576554 HELA 1.11 uM 24 h 0.0 0.0 0.0 -0.24 -0.79 0.11
121455 BRD-K24576554 HT29 1.11 uM 24 h 0.27 1.15 0.32 0.0 0.0 0.0
121491 BRD-K24576554 PC3 0.04 uM 24 h -0.24 -0.98 0.12 0.0 0.0 0.0
121547 BRD-K24576554 YAPC 10 uM 24 h 0.23 0.98 0.09 0.0 0.0 0.0
129543 BRD-K24576554 MCF??7.00 0.08 uM 24 h 0.0 0.0 0.0 -0.18 -0.62 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).