CMap Candidate Details

Structure:
CMap ID: C10213
Pert ID: BRD-K24666289
Compound Name: copanlisib
Targets: PIK3CA; PIK3CD
MoA: PI3K inhibitor
SMILES: COc1c(OCCCN2CCOCC2)ccc2C3=NCCN3C(NC(=O)c3cnc(N)nc3)=Nc12
InchiKey: PZBCKZWLPGJMAO-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
482 BRD-K24666289 BJAB 10 uM 24 h 0.24 0.98 0.09 0.0 0.0 0.0
549 BRD-K24666289 HBL1 10 uM 4 h 0.0 0.0 0.0 0.41 1.44 2.21
590 BRD-K24666289 K562 10 uM 4 h 0.0 0.0 0.0 -0.38 -1.27 1.44
620 BRD-K24666289 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
665 BRD-K24666289 MINO 2.5 uM 24 h -0.23 -0.98 0.12 0.28 1.0 0.42
713 BRD-K24666289 NALM6 2.5 uM 24 h 0.18 0.74 0.0 0.0 0.0 0.0
754 BRD-K24666289 OCILY19 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
803 BRD-K24666289 OCILY3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
854 BRD-K24666289 SKMEL5 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
900 BRD-K24666289 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
955 BRD-K24666289 TMD8 10 uM 4 h 0.23 0.94 0.06 0.17 0.6 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).