CMap Candidate Details

Structure:
CMap ID: C10219
Pert ID: BRD-K24681473
Compound Name: YM-155
Targets: BIRC5
MoA: Survivin inhibitor
SMILES: COCC[n+]1c(C)n(Cc2cnccn2)c2c1C(=O)c1ccccc1C2=O
InchiKey: OTSOOHRUMBRSHZ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1338 BRD-K24681473 U2OS 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
29811 BRD-K24681473 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
30179 BRD-K24681473 A549 10 uM 6 h -0.32 -1.35 0.98 0.0 0.0 0.0
30399 BRD-K24681473 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
30712 BRD-K24681473 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
30999 BRD-K24681473 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31304 BRD-K24681473 HEPG2 10 uM 6 h -0.21 -0.86 0.02 0.0 0.0 0.0
31506 BRD-K24681473 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
32007 BRD-K24681473 MCF??7.00 10 uM 6 h -0.23 -0.96 0.1 -0.46 -1.56 15.65
32751 BRD-K24681473 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
32983 BRD-K24681473 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33263 BRD-K24681473 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.41 -1.39 2.02
95995 BRD-K24681473 PHH 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).